Research Consortium Database PDF Print E-mail

THE CENTERPIECE: A Shared Clinical Database for Alzheimer's Research

The Consortium's data coordinating system is a unique resource for Texas - providing a large, common, standardized database to facilitate collaborative studies of Alzheimer’s disease among four of the state's leading medical institutions. The database consists of two major components:

• The Minimum Data Set (MDS) includes cross-sectional clinical and demographic data on more than 2,000 subjects recruited at Consortium member sites between January 2001 and April 2010 and

• The Longitudinal Data Set (LDS) integrates with the MDS and consists of expanded clinical data collected annually across all Consortium member sites following standardized protocols. Over 1500 active participants are enrolled in the LDS Data Set, including over 500 Hispanic individuals.

The LDS data will support projects designed to identify genetic factors and biomarkers associated with Alzheimer’s disease. Biomarkers are molecular, biological, or physical characteristics that can indicate a specific, underlying physiologic state or disease.

Analysis of the LDS will enable TARCC investigators to model changes in cognitive function over time, enabling identification of factors that affect not only risk, but disease progression. The inclusion of individuals diagnosed with mild cognitive impairment (MCI) will facilitate these efforts as well as increase the scientific value of the data derived. The longitudinal and multi-institutional nature of the Consortium’s study design makes it unique among Alzheimer’s disease research efforts.

Number of Subjects by Diagnosis & Visit Number as of February 2013

Visit Number
Diagnosis 1 2 3 4 567
Alzheimer's disease 1044 725 485 293 163 75 9 0
Mild Cognitive Impairment 440 233 132 23 1 1 1 0
Controls 1068 679 530 326 233 120 31 1
Total 2,560 1,639
1,147 642397196411

Current Number of Active Subjects as of February 2013

Diagnosis Total Hispanic
Alzheimer’s Disease 517 90
Mild Cognitive Impairment 379
Controls 864
Total 1,760 718

Texas Alzheimer’s Research and Care Consortium

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Alzheimer's Facts

By 2030, all baby boomers will be 65 or older.  That year, the national Alzheimer's Association projects that 7.7 million in that age group will have Alzheimer's.