Investigator Grants

//Investigator Grants
Investigator Grants2020-11-17T17:34:25-05:00

In 2014, the Texas Council on Alzheimer’s Disease and Related Disorders launched the inaugural Investigator Grant Program for the Texas Alzheimer’s Research and Care Consortium (TARCC), as part of the state-funded Darrell K Royal Texas Alzheimer’s Initiative. This grant program provided financial support to Texas researchers to promote novel research and discovery towards understanding biological mechanisms, improving diagnosis, and developing therapies for Alzheimer’s disease.

Since 2007 a four (4) member External Advisory Committee comprised of out-of-state distinguished, nationally prominent research scientists and medical doctors, led by Dr. Ron Petersen at Mayo Clinic, have regularly met with Steering Committee and Council representatives to conduct a detailed review of all TARCC scientific activities and grant awards to assure that the investments made by the Texas Legislature are advancing the best science of AD research.

In 2018, with a mature database of 3,670 cases accumulated by TARCC investigators across the state, the Council approved a transition from a cohort surveillance model to a grants-based program. The TARCC Investigator Grants Program aims to support the best science in the state while enhancing TARCC cohort data utilization and scientific productivity.

2020 Postdoctoral Fellowship Grants

Recipient

Grant Title

Jennifer Johnson, PhD

The role of a lipid metabolism pathway in regulating APP levels and processing

2020 Junior Investigator Research Grants

Recipient

Grant Title

Lu Sun, PhD

Characterization of a New Risk Cell Type in Alzheimer's Disease

Anne Carlew, PhD

Utility of Neuropsychological Methods to Improve Diagnostic Accuracy of Mild Cognitive Impairment

Bharti Manwani, PhD

Sexual Dimorphism in Cerebral Amyloid Angiopathy and Vascular Dementia: Investigating the Role of Fibrinolytic System

Hua Liu, PhD

Investigation of Retinal Vascular Changes in Tauopathy

Fang Yu, MD

A Novel MRI Biomarker for Brain Tau Deposition

2020 Investigator Initiated Research Grants

Recipient

Grant Title

John Hart, Jr, MD

Longitudinal Continuation of TARCC Hispanic Cohort (Neurological, Neuropsychological, Cerebrospinal, MRI Morphometrics, and Resting-state fMRI Measures)

Charles L. White, III, MD

Texas Statewide Brain Bank Initiative

Shannon Juengst, PhD

Problem solving training (PST) for English- and Spanish-speaking care partners of adults with Alzheimer's and Alzheimer's-related dementia

Claudia Satizabal, PhD

Characterization of Microbial Composition in Alzheimer's Disease

Joann Jankowsky, PhD

Gene therapy for Alzheimer's disease using virally delivered A-beta variants

Chun-Li Zhang, PhD

Therapeutic Targets for Alzheimer's Disease in Aging-relevant Human Neurons

Antonio Lucio Teixeira, Jr, MD, PhD

Home-based tDCS for apathy in Alzheimer's Disease

Satwik Rajaram, PhD

Characterization of White Matter Pathology In Tauopathies Using Machine Learning

Mohammad Shahnawaz, PhD

Detection of Misfolded Tau Oligometers in Biological Fluid for the Diagnosis of Alzheimer's Disease and Disease Monitoring

Nicole Phillips, PhD

Longitudinal Mitochondrial DNA and microRNA Profiling of Neuron-enriched Exosomes Associated with Cognitive Decline in Mexican Americans

2019 Fellowship Grants

Recipient

Grant Title

Kelly Dineley, PhD

Training Fellowship in Aging and AD Research and Care

Robin Hilsabeck, PhD

Neuropsychology Fellowship Program

Laura Lacritz, PhD

Neuropsychology of Dementia Fellowship

2018 Investigator Initiated Grants

Recipient

Grant Title

John Hart, Jr, MD

Longitudinal Continuation of TARCC Hispanic Cohort (Collaborative Multi-Site Award)

Marcia Ory, PhD

Assessing the utility and effectiveness of monitoring technology for reducing caregiver burden for Alzheimer’s Disease (Collaborative Multi-Site Award)

Robert Barber, PhD

Epigenetic risk factors for age at onset of Alzheimer’s & MCI and metabolic dysfunction among non-Caribbean Hispanics and non-Hispanic whites

Hugo Bellen, DVM, PhD

Probing the role of glial endocytic genes and ROS on AB42-induced neurotoxicity

Dwight German, PhD

Blood biomarker for Alzheimer’s Disease & disease progression: Phospholipids

Rakez Kayed, PhD

Multi target combinatory therapy for Alzheimer’s Disease

Alicia Parker, MD

Diastolic dysfunction and the development of dementia

2018 Junior Investigator Grants

Recipient

Grant Title

Mitzi Gonzales, PhD

Establishing novel blood-based biomarkers for Alzheimer’s Disease in the Texas Alzheimer’s Research and Care Consortium

Ryan Huebinger, PhD

Immune profile investigations of Alzheimer’s Disease

Ines Moreno-Gonzalez, PhD

Stem cell-derived anti-inflammatory treatment for Alzheimer’s disease

Trung Nguyen, MD, PhD

Tau seeding and strain identification across the spectrum of Alzheimer’s Disease and Lewy Body pathology

Sandra Pritzkow, PhD

Development of a blood test for Alzheimer’s disease diagnosis

Sangram Raut, PhD

Brain targeted RNAi therapy for Alzheimer’s Disease

2014 Pilot Grants

Recipient

Grant Title

Ren-Qi Huang, PhD

Neuroprotection of nonfeminizing estrogens against cognitive deficits of Alzheimer’s Disease.

Steven Patrie, PhD

Computational tools for molecular proteotyping: A unique approach to Alzheimer’s disease biomarker discovery.

Anson Pierce, PhD

Does HSF1 over-expression enhance the proteostasis of TDP-43?

Paul C. Trippier, PhD

Identification of Aß-ABAD Interaction Inhibitors for Evaluation as Small Molecule.

Akihiko Urayama, PhD

Effect of Youthful Systemic Milieu on Alzheimer’s Disease Patholog

2014 Established Investigator Grants

Recipient

Grant Title

Xiangrong Shi, PhD

Intermittent Hypoxia – novel intervention for treatment of mild cognitive impairment.

Huda Zoghbi, MD

A cross-species genetic screen to identify targets that regulate the steady state levels of tau.