The Texas Harris Alzheimer's Research Study is a large, standardized research database containing integrated psychometric, medical and genetic data, biological markers, whole blood, serum, plasma and DNA on Texas Alzheimer's Research and Care Consortium (TARCC) study participants. To date, TARCC has enrolled more than 3000 study participants diagnosed with Alzheimer's disease (AD), mild cognitive impairment (MCI), and cognitively healthy controls subjects (NC) into the research study. The inclusion of individuals diagnosed with mild cognitive impairment helps in our understanding of the sequence of neurodegenerative changes that occur as AD develops. TARCC enrollment is ongoing and includes replacement allowance for individuals lost to follow up.
A unique strength of TARCC is the enrollment of the largest number of Mexican American participants in an ongoing AD research study. Mexican Americans are the fastest growing ethnic group in Texas and are projected to represent a majority of the state's population by 2020 and very little is known about AD in this population.
A novel and important strength of TARCC is the longitudinal nature of the study, where participants are followed annually. The current active number of participants is 1730, including nearly 800 Mexican American participants. Analysis of the longitudinal data allows TARCC investigators to model changes in cognitive function over time, allowing for the identification of factors that affect not only risk, but also disease progression.
The wealth of information contained in the Texas Harris Alzheimer's Research Study stimulates novel, basic and clinical research that furthers understanding of AD as well as facilitates collaborative research projects among Texas AD researchers. A number of significant research developments have resulted from analysis of the Texas Harris Alzheimer's Research Study data.
TARCC is a valuable resource to state and national AD research efforts because of the longitudinal nature of the data collected, the inclusion of Mexican Americans, and the availability of genetic and biomarker samples. Wider utilization of this unique resource by a diverse group of AD researchers, both in Texas and across the nation is encouraged to advance AD research efforts. For investigators interested in using TARCC data for research projects, see the Project Proposal and Data Request Form below.