Data and Sample requests may be made through the following link.
TARCC maintains a biorepository of blood specimens that correspond to annual visits of TARCC participants. These blood specimens include Serum, Plasma, whole blood, buffy coat, and DNA. In addition to the data points listed in the data variables spreadsheet, Genetic I and Genetics II data is also available for many of the TARCC participants, as follows:
Affymetrix Genome-Wide Human SNP Array 6.0 (Affymetrix, Santa Clara, CA), which includes 906,600 single nucleotide polymorphism (SNP) and 946,000 copy number variation (CNV) markers. The new Affymetrix Genome-Wide Human SNP Array 6.0 features 1.8 million genetic markers, including more than 906,600 SNPs and more than 946,000 probes for the detection of CNV. The SNP Array 6.0 is the only platform with analysis tools to truly bridge copy number and association, including a new, high-resolution reference map and a copy number polymorphism calling algorithm developed by the Broad Institute.
Illumina Multi-Ethnic Global Array (MEGA) (Illumina, San Diego, CA), which includes 2,036,060 SNP markers. The Expanded Multi-Ethnic Genotyping Array (MEGAEX) leverages content from Phase 3 of the 1000 Genomes Project (1kGP)1, Consortium on Asthma among African-ancestry Populations in the Americas (CAAPA), Population Architecture using Genomics and Epidemiology (PAGE), T2D-Genes Consortium, OMIM, ClinVar, ACGM, carrier screening panels, and other resources to create a true multipurpose, multiethnic array.
If you would like any specific information about available genetics data, how many subjects we have with a certain diagnosis, or answered a question a certain way, or some other feasibility issue before you submit a full application, please email TARCC@UTSouthwestern.edu. Our database administrator will help you with this information. For any other questions please also contact TARCC@UTSouthwestern.edu.
When using this data set, to ensure proper acknowledgement is given to the state of Texas and to the Texas Council on Alzheimer’s disease and Related Disorders, the following Statement of Acknowledgement must be included in all publications, printed materials and deliverables:
"This study was made possible (*in part if necessary) by the Texas Alzheimer’s Research and Care Consortium (TARCC) funded by the state of Texas through the Texas Council on Alzheimer’s Disease and Related Disorders.”