Data and Sample Information and Requests

//Data and Sample Information and Requests
Data and Sample Information and Requests2021-05-12T15:46:27-05:00

TARCC maintains a biorepository of blood specimens that correspond to annual visits of TARCC participants. These blood specimens include Serum, Plasma, whole blood, buffy coat, and DNA. In addition to the data points listed in the data variables spreadsheet, Genetic I and Genetics II data is also available for many of the TARCC participants, as follows:

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Affymetrix Genome-Wide Human SNP Array 6.0 (Affymetrix, Santa Clara, CA), which includes 906,600 single nucleotide polymorphism (SNP) and 946,000 copy number variation (CNV) markers. The new Affymetrix Genome-Wide Human SNP Array 6.0 features 1.8 million genetic markers, including more than 906,600 SNPs and more than 946,000 probes for the detection of CNV. The SNP Array 6.0 is the only platform with analysis tools to truly bridge copy number and association, including a new, high-resolution reference map and a copy number polymorphism calling algorithm developed by the Broad Institute.

Illumina Multi-Ethnic Global Array (MEGA) (Illumina, San Diego, CA), which includes 2,036,060 SNP markers. The Expanded Multi-Ethnic Genotyping Array (MEGAEX) leverages content from Phase 3 of the 1000 Genomes Project (1kGP)1, Consortium on Asthma among African-ancestry Populations in the Americas (CAAPA), Population Architecture using Genomics and Epidemiology (PAGE), T2D-Genes Consortium, OMIM, ClinVar, ACGM, carrier screening panels, and other resources to create a true multipurpose, multiethnic array.

If you would like any specific information about available genetics data, how many subjects we have with a certain diagnosis, or answered a question a certain way, or some other feasibility issue before you submit a full application, please email TARCC@UTSouthwestern.edu. Our database administrator will help you with this information. For any other questions please also contact TARCC@UTSouthwestern.edu.

When using this data set, to ensure proper acknowledgement is given to the state of Texas and to the Texas Council on Alzheimer’s disease and Related Disorders, the following Statement of Acknowledgement must be included in all publications, printed materials and deliverables:
"This study was made possible (*in part if necessary) by the Texas Alzheimer’s Research and Care Consortium (TARCC) funded by the state of Texas through the Texas Council on Alzheimer’s Disease and Related Disorders.

Recently Approved Projects Requesting Data and/or Samples

Exploring the neurocognitive links in Alzheimer’s disease: A network study
Adam Calderon, MA
Columbia University and the Fulbright Program at the Hungarian Academy of Sciences

Comparing serum-based biomarkers associated with AD across technological platforms
Sid O’Bryant, PhD
University of North Texas Health Science Center

The genetic basis of Alzheimer disease in Hispanic Americans affected by type-2 diabetes
Upal Roy, PhD
UT Health Rio Grande Valley

Blood Biomarker for Alzheimer's Disease & Disease Progression: Phospholipids
Dwight German, PhD
UT Southwestern

Neuropsychological predictors of time to conversion from mild cognitive impairment to Alzheimer's disease
Allison Parker
UT Southwestern

Predictive utility of cognitive intraindividual variability in the TARCC cohort
Bonnie M. Scott, PhD
UT Austin Dell Medical School

Dynamic modeling, prediction and identification of significant prognostic factors of Alzheimer's disease
Liang Zhu, PhD
UT Health Houston

Cracking the Latino paradox: The role of social isolation as a predictor of cognitive performance in Hispanics
Mirna Luz Arroyo-Miranda, JD, DrPH
University of Houston

Assessing sex differences in gut metabolites in AD/MCI patients
Farida Sohrabji, PhD
Texas A&M University Health Science Center

Role of indoles in delaying the onset of Alzheimer's disease
Xiang Fang, MD, PhD, FAAN, FANA
UT Medical Branch at Galveston

An initial study of health aging and Alzheimer's disease (AD) among Hispanic population: interactions of lifestyle and genes
Chun Zu, MD, PhD, MSc
UT Health Rio Grande Valley

Inflammatory phenotype associated with the uniquely human gene CHRFAM7A in blood-based biomarkers
Kinga Szigeti, MD, PhD
University at Buffalo

Investigating the role of inflammation on apathy in Alzheimer's disease
Antonio Teixeira, MD, PhD, MSc
UT Health Houston

Latent class modelling of a diverse clinical sample: Identification of unique trends and patterns of performance in neuropsychological measures
William Goette
UT Southwestern

Genetics of Alzheimer's disease across the spectrum of ancestry, age, sex, and APOE4
Michael Belloy, PhD
Stanford University

Addressing model misspecification to profile Alzheimer patient subgroups for precise clinical trials
Tanya Garcia, PhD
Texas A&M University

Reinforcement learning for medication and diagnosis of Alzheimer's disease
Yejin Kim, PhD
UT Health Houston

Adaptation and application of an actuarial neuropsychological diagnostic algorithm to the Texas Alzheimer's Research and Care Consortium's database
William Goette
UT Southwestern

The relationship between the cognitive impairment, neuropsychiatric disturbances and activities in daily living in patients with MCI and Alzheimer's disease
Parunyou Julayanont, MD
Texas Tech University Health Science Center

Detection of Aldolase A in human clinical samples towards early detection of Alzheimer’s disease progression
Balaji Krishnan, PhD
UT Medical Branch at Galveston